Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery\nsystems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by\nstereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM\nprocess combining SLA with inkjet printing was successfully implemented in an existing SLA test\nsetup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots\nwere generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum\nalbumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside\na DDS. The new hybrid AM process makes it possible to place several drugs independently of each\nother within the matrix. This allows adjustment of the release profiles of the drugs depending on the\nsize as well as the position of the depots in the DDS.
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